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Crystal structure of IP-10 M-form

X-ray diffraction
3Å resolution
PDB entry 1o7y coloured by chain, front view.
PDB entry 1o7y coloured by chain, side view.
PDB entry 1o7y coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: C-X-C motif chemokine 10
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Multimeric state: homo tetramer
Accessible surface area: 14395.67 Å2
Buried surface area: 4961.46 Å2
Dissociation area: 2,305.94 Å2
Dissociation energy (ΔGdiss): 8.44 kcal/mol
Dissociation entropy (TΔSdiss): 31.53 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-136206

Macromolecules

C-X-C motif chemokine 10
Chains: A, B, C, D
Length: 77 amino acids
Theoretical weight: 8.64 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02778 (Residues: 22-98; Coverage: 100%)
Gene names: CXCL10, INP10, SCYB10
Pfam: Small cytokines (intecrine/chemokine), interleukin-8 like
InterPro:
CATH: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
SCOP: Interleukin 8-like chemokines
C-X-C motif chemokine 10 in PDB entry 1o7y, assembly 1, front view.
C-X-C motif chemokine 10 in PDB entry 1o7y, assembly 1, side view.
C-X-C motif chemokine 10 in PDB entry 1o7y, assembly 1, top view.
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