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A 1:1 complex between alpha-lactalbumin and beta1,4-galactosyltransferase in the presence of UDP-N-acetyl-galactosamine

Source organisms:
Biochemical function: glycosyltransferase activity
Biological process: carbohydrate metabolic process
Cellular component: protein-containing complex

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EC 2.4.1.90: N-acetyllactosamine synthase

Reaction catalysed:
UDP-alpha-D-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine
Systematic name:
UDP-alpha-D-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
Alternative Name(s):
  • Acetyllactosamine synthetase
  • Beta-1,4-galactosyltransferase
  • Beta-1-4-galactosyltransferase
  • Beta-1-4GalT
  • Beta-N-acetylglucosaminide beta-1-4-galactosyltransferase
  • Gal-T
  • Lactosamine synthase
  • Lactosamine synthetase
  • Lactose synthetase A protein
  • N-acetylglucosamine (beta-1,4)galactosyltransferase
  • N-acetyllactosamine synthetase
  • NAL synthetase
  • UDP-Gal:N-acetylglucosamine beta-1-4-galactosyltransferase
  • UDP-beta-1,4-galactosyltransferase
  • UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase
  • UDP-galactose--N-acetylglucosamine beta-D-galactosyltransferase
  • UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase
  • UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase
  • UDP-galactose-N-acetylglucosamine galactosyltransferase
  • UDP-galactose-acetylglucosamine galactosyltransferase
  • UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase
  • UDP-galactose:N-acetylglucosaminide beta-1-4-galactosyltransferase
  • UDPgalactose:N-acetylglucosaminyl(beta-1-4)galactosyltransferase
  • Uridine diphosphogalactose-acetylglucosamine galactosyltransferase

EC 2.4.1.38: Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase

Reaction catalysed:
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide
Systematic name:
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
Alternative Name(s):
  • Beta-N-acetyl-beta-1-4-galactosyltransferase
  • GalT
  • Glycoprotein 4-beta-galactosyl-transferase
  • Glycoprotein 4-beta-galactosyltransferase
  • Glycoprotein beta-galactosyltransferase
  • Thyroid galactosyltransferase
  • Thyroid glycoprotein beta-galactosyltransferase
  • UDP-galactose--glycoprotein galactosyltransferase
  • UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide 4-beta-galactosyltransferase
  • UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase
  • UDPgalactose-glycoprotein galactosyltransferase
  • UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase
  • Uridine diphosphogalactose-glycoprotein galactosyltransferase

EC 2.4.1.275: Neolactotriaosylceramide beta-1,4-galactosyltransferase

Reaction catalysed:
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Systematic name:
UDP-alpha-D-galactose:N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 4-beta-D-galactosyltransferase
Alternative Name(s):
  • Beta-4Gal-T4
  • Lactotriaosylceramide beta-1,4-galactosyltransferase
  • UDP-galactose:N-acetyl-beta-D-galactosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide beta-1,4-galactosyltransferase

EC 2.4.1.22: Lactose synthase

Reaction catalysed:
UDP-alpha-D-galactose + D-glucose = UDP + lactose
Systematic name:
UDP-alpha-D-galactose:D-glucose 4-beta-D-galactosyltransferase
Alternative Name(s):
  • Lactose synthetase
  • N-acetyllactosamine synthase
  • UDP-galactose--glucose galactosyltransferase
  • UDP-galactose:D-glucose 4-beta-D-galactosyltransferase
  • UDP-galactose:D-glucose 4-beta-D-galactotransferase
  • Uridine diphosphogalactose-glucose galactosyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02709
Domain description: N-terminal domain of galactosyltransferase
Occurring in:
  1. Beta-1,4-galactosyltransferase 1
The deposited structure of PDB entry 1oqm contains 2 copies of Pfam domain PF02709 (N-terminal domain of galactosyltransferase) in Beta-1,4-galactosyltransferase 1. Showing 1 copy in chain B.

PF13733
Domain description: N-terminal region of glycosyl transferase group 7
Occurring in:
  1. Beta-1,4-galactosyltransferase 1
The deposited structure of PDB entry 1oqm contains 2 copies of Pfam domain PF13733 (N-terminal region of glycosyl transferase group 7) in Beta-1,4-galactosyltransferase 1. Showing 1 copy in chain B.

PF00062
Domain description: C-type lysozyme/alpha-lactalbumin family
Occurring in:
  1. Alpha-lactalbumin
The deposited structure of PDB entry 1oqm contains 2 copies of Pfam domain PF00062 (C-type lysozyme/alpha-lactalbumin family) in Alpha-lactalbumin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001916
Domain description: Glycoside hydrolase, family 22
Occurring in:
  1. Alpha-lactalbumin
IPR003859
Domain description: Beta-1,4-galactosyltransferase
Occurring in:
  1. Beta-1,4-galactosyltransferase 1
IPR000545
Domain description: Lactalbumin
Occurring in:
  1. Alpha-lactalbumin
IPR029044
Domain description: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Beta-1,4-galactosyltransferase 1
IPR027791
Domain description: Galactosyltransferase, C-terminal
Occurring in:
  1. Beta-1,4-galactosyltransferase 1
IPR027995
Domain description: Galactosyltransferase, N-terminal
Occurring in:
  1. Beta-1,4-galactosyltransferase 1
IPR019799
Domain description: Glycoside hydrolase family 22 domain
Occurring in:
  1. Alpha-lactalbumin
IPR023346
Domain description: Lysozyme-like domain superfamily
Occurring in:
  1. Alpha-lactalbumin

Structure domains

CATH CATH domains
3.90.550.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homology: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Occurring in:
  1. Beta-1,4-galactosyltransferase 1
The deposited structure of PDB entry 1oqm contains 2 copies of CATH domain 3.90.550.10 (Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A) in Beta-1,4-galactosyltransferase 1. Showing 1 copy in chain B.
1.10.530.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Lysozyme
Homology: Lysozyme
Occurring in:
  1. Alpha-lactalbumin
The deposited structure of PDB entry 1oqm contains 2 copies of CATH domain 1.10.530.10 (Lysozyme) in Alpha-lactalbumin. Showing 1 copy in chain A.
SCOP SCOP annotations
53452
Class: Alpha and beta proteins (a/b)
Fold: Nucleotide-diphospho-sugar transferases
Superfamily: Nucleotide-diphospho-sugar transferases
Occurring in:
  1. Beta-1,4-galactosyltransferase 1
The deposited structure of PDB entry 1oqm contains 2 copies of SCOP domain 53452 (beta 1,4 galactosyltransferase (b4GalT1)) in Beta-1,4-galactosyltransferase 1. Showing 1 copy in chain B.
53960
Class: Alpha and beta proteins (a+b)
Fold: Lysozyme-like
Superfamily: Lysozyme-like
Occurring in:
  1. Alpha-lactalbumin
The deposited structure of PDB entry 1oqm contains 2 copies of SCOP domain 53960 (C-type lysozyme) in Alpha-lactalbumin. Showing 1 copy in chain A.

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