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CRYSTALLOGRAPHIC STUDY OF COENZYME, COENZYME ANALOGUE AND SUBSTRATE BINDING IN 6-PHOSPHOGLUCONATE DEHYDROGENASE: IMPLICATIONS FOR NADP SPECIFICITY AND THE ENZYME MECHANISM

X-ray diffraction
2.5Å resolution
PDB entry 1pgp coloured by chain, front view.
PDB entry 1pgp coloured by chain, side view.
PDB entry 1pgp coloured by chain, top view.
Source organism: Ovis aries
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 6-phosphogluconate dehydrogenase, decarboxylating
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Multimeric state: homo dimer
Accessible surface area: 33696.0 Å2
Buried surface area: 12599.21 Å2
Dissociation area: 5,688.87 Å2
Dissociation energy (ΔGdiss): 101.13 kcal/mol
Dissociation entropy (TΔSdiss): 15.88 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-132423

Macromolecules

6-phosphogluconate dehydrogenase, decarboxylating
Chain: A
Length: 482 amino acids
Theoretical weight: 52.91 KDa
Source organism: Ovis aries
Expression system: Not provided
UniProt:
  • Canonical: P00349 (Residues: 2-483; Coverage: 100%)
Gene name: PGD
Pfam:
InterPro:
CATH:
SCOP:
6-phosphogluconate dehydrogenase, decarboxylating in PDB entry 1pgp, assembly 1, front view.
6-phosphogluconate dehydrogenase, decarboxylating in PDB entry 1pgp, assembly 1, side view.
6-phosphogluconate dehydrogenase, decarboxylating in PDB entry 1pgp, assembly 1, top view.
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