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Human L-Xylulose Reductase Holoenzyme

X-ray diffraction
1.96Å resolution
PDB entry 1pr9 coloured by chain, front view.
PDB entry 1pr9 coloured by chain, side view.
PDB entry 1pr9 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: L-xylulose reductase
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Multimeric state: homo dimer
Accessible surface area: 21160.85 Å2
Buried surface area: 4244.42 Å2
Dissociation area: 295.13 Å2
Dissociation energy (ΔGdiss): -11.55 kcal/mol
Dissociation entropy (TΔSdiss): 12.66 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-182274
Assembly 2
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Assembly Name: L-xylulose reductase
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Multimeric state: homo tetramer
Accessible surface area: 29907.33 Å2
Buried surface area: 20917.91 Å2
Dissociation area: 3,408.87 Å2
Dissociation energy (ΔGdiss): 50.53 kcal/mol
Dissociation entropy (TΔSdiss): 14.83 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-182276

Macromolecules

L-xylulose reductase
Chains: A, B
Length: 244 amino acids
Theoretical weight: 25.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q7Z4W1 (Residues: 1-244; Coverage: 100%)
Gene names: DCXR, SDR20C1
Pfam: Enoyl-(Acyl carrier protein) reductase
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain
SCOP: Tyrosine-dependent oxidoreductases
L-xylulose reductase in PDB entry 1pr9, assembly 1, front view.
L-xylulose reductase in PDB entry 1pr9, assembly 1, side view.
L-xylulose reductase in PDB entry 1pr9, assembly 1, top view.
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