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X-Ray Crystal Structure of the SARS Coronavirus Main Protease

X-ray diffraction
1.86Å resolution
PDB entry 1q2w coloured by chain, front view.
PDB entry 1q2w coloured by chain, side view.
PDB entry 1q2w coloured by chain, top view.
Source organism: Severe acute respiratory syndrome-related coronavirus
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3C-like proteinase nsp5
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Multimeric state: homo dimer
Accessible surface area: 25644.48 Å2
Buried surface area: 2471.54 Å2
Dissociation area: 1,057.68 Å2
Dissociation energy (ΔGdiss): 4.42 kcal/mol
Dissociation entropy (TΔSdiss): 13.72 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-143077

Macromolecules

3C-like proteinase nsp5
Chains: A, B
Length: 308 amino acids
Theoretical weight: 33.99 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0C6U8 (Residues: 3241-3544; Coverage: 7%)
Gene name: 1a
Pfam: Coronavirus endopeptidase C30
InterPro:
CATH:
SCOP: Viral cysteine protease of trypsin fold
3C-like proteinase nsp5 in PDB entry 1q2w, assembly 1, front view.
3C-like proteinase nsp5 in PDB entry 1q2w, assembly 1, side view.
3C-like proteinase nsp5 in PDB entry 1q2w, assembly 1, top view.
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