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THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 4

X-ray diffraction
2.1Å resolution
PDB entry 1q6n coloured by chain, front view.
PDB entry 1q6n coloured by chain, side view.
PDB entry 1q6n coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 1
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Multimeric state: monomeric
Accessible surface area: 13355.81 Å2
Buried surface area: 1220.34 Å2
Dissociation area: 26.53 Å2
Dissociation energy (ΔGdiss): 4.28 kcal/mol
Dissociation entropy (TΔSdiss): -1.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148259
Assembly 2
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 1
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Multimeric state: monomeric
Accessible surface area: 13165.81 Å2
Buried surface area: 1163.2 Å2
Dissociation area: 9.27 Å2
Dissociation energy (ΔGdiss): 2.08 kcal/mol
Dissociation entropy (TΔSdiss): -1.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148259

Macromolecules

Tyrosine-protein phosphatase non-receptor type 1
Chains: A, B
Length: 310 amino acids
Theoretical weight: 36.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P18031 (Residues: 1-298; Coverage: 69%)
Gene names: PTP1B, PTPN1
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
SCOP: Higher-molecular-weight phosphotyrosine protein phosphatases
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1q6n, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1q6n, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 1 in PDB entry 1q6n, assembly 1, top view.
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