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Structural basis of oligomannose recognition by the Pterocarpus angolensis seed lectin.

Loris R, Van Walle I, De Greve H, Beeckmans S, Deboeck F, Wyns L, Bouckaert J
J Mol Biol 335 1227-40 (2004)
Related entries: 1q8o, 1q8p, 1q8q, 1q8s, 1ukg

Cited: 27 times
EuropePMC logo PMID: 14729339

Abstract

The crystal structure of a Man/Glc-specific lectin from the seeds of the bloodwood tree (Pterocarpus angolensis), a leguminous plant from central Africa, has been determined in complex with mannose and five manno-oligosaccharides. The lectin contains a classical mannose-specificity loop, but its metal-binding loop resembles that of lectins of unrelated specificity from Ulex europaeus and Maackia amurensis. As a consequence, the interactions with mannose in the primary binding site are conserved, but details of carbohydrate-binding outside the primary binding site differ from those seen in the equivalent carbohydrate complexes of concanavalin A. These observations explain the differences in their respective fine specificity profiles for oligomannoses. While Man(alpha1-3)Man and Man(alpha1-3)[Man(alpha1-6)]Man bind to PAL in low-energy conformations identical with that of ConA, Man(alpha1-6)Man is required to adopt a different conformation. Man(alpha1-2)Man can bind only in a single binding mode, in sharp contrast to ConA, which creates a higher affinity for this disaccharide by allowing two binding modes.

Reviews - 1q8v mentioned but not cited (2)

  1. Man-Specific Lectins from Plants, Fungi, Algae and Cyanobacteria, as Potential Blockers for SARS-CoV, MERS-CoV and SARS-CoV-2 (COVID-19) Coronaviruses: Biomedical Perspectives. Barre A, Van Damme EJM, Simplicien M, Le Poder S, Klonjkowski B, Benoist H, Peyrade D, Rougé P. Cells 10 1619 (2021)
  2. Overview of the Structure⁻Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi. Barre A, Bourne Y, Van Damme EJM, Rougé P. Int J Mol Sci 20 E254 (2019)

Articles - 1q8v mentioned but not cited (2)



Articles citing this publication (23)

  1. Phytohemagglutinin from Phaseolus vulgaris (PHA-E) displays a novel glycan recognition mode using a common legume lectin fold. Nagae M, Soga K, Morita-Matsumoto K, Hanashima S, Ikeda A, Yamamoto K, Yamaguchi Y. Glycobiology 24 368-378 (2014)
  2. Native crystal structure of a nitric oxide-releasing lectin from the seeds of Canavalia maritima. Gadelha CA, Moreno FB, Santi-Gadelha T, Cajazeiras JB, Rocha BA, Assreuy AM, Lima Mota MR, Pinto NV, Passos Meireles AV, Borges JC, Freitas BT, Canduri F, Souza EP, Delatorre P, Criddle DN, de Azevedo WF, Cavada BS. J Struct Biol 152 185-194 (2005)
  3. Vasodilator effects of Diocleinae lectins from the Canavalia genus. Assreuy AM, Fontenele SR, Pires Ade F, Fernandes DC, Rodrigues NV, Bezerra EH, Moura TR, do Nascimento KS, Cavada BS. Naunyn Schmiedebergs Arch Pharmacol 380 509-521 (2009)
  4. NMR and Molecular Recognition of N-Glycans: Remote Modifications of the Saccharide Chain Modulate Binding Features. Gimeno A, Reichardt NC, Cañada FJ, Perkams L, Unverzagt C, Jiménez-Barbero J, Ardá A. ACS Chem Biol 12 1104-1112 (2017)
  5. Structural analysis of Canavalia maritima and Canavalia gladiata lectins complexed with different dimannosides: new insights into the understanding of the structure-biological activity relationship in legume lectins. Bezerra GA, Oliveira TM, Moreno FB, de Souza EP, da Rocha BA, Benevides RG, Delatorre P, de Azevedo WF, Cavada BS. J Struct Biol 160 168-176 (2007)
  6. Structural analysis of ConBr reveals molecular correlation between the carbohydrate recognition domain and endothelial NO synthase activation. Bezerra EH, Rocha BA, Nagano CS, Bezerra Gde A, Moura TR, Bezerra MJ, Benevides RG, Sampaio AH, Assreuy AM, Delatorre P, Cavada BS. Biochem Biophys Res Commun 408 566-570 (2011)
  7. Structural studies of an anti-inflammatory lectin from Canavalia boliviana seeds in complex with dimannosides. Bezerra GA, Viertlmayr R, Moura TR, Delatorre P, Rocha BA, do Nascimento KS, Figueiredo JG, Bezerra IG, Teixeira CS, Simões RC, Nagano CS, de Alencar NM, Gruber K, Cavada BS. PLoS One 9 e97015 (2014)
  8. Crystal structure of Dioclea violacea lectin and a comparative study of vasorelaxant properties with Dioclea rostrata lectin. Bezerra MJ, Rodrigues NV, Pires Ade F, Bezerra GA, Nobre CB, Alencar KL, Soares PM, do Nascimento KS, Nagano CS, Martins JL, Gruber K, Sampaio AH, Delatorre P, Rocha BA, Assreuy AM, Cavada BS. Int J Biochem Cell Biol 45 807-815 (2013)
  9. Crystal structure of a lectin from Canavalia maritima (ConM) in complex with trehalose and maltose reveals relevant mutation in ConA-like lectins. Delatorre P, Rocha BA, Gadelha CA, Santi-Gadelha T, Cajazeiras JB, Souza EP, Nascimento KS, Freire VN, Sampaio AH, Azevedo WF, Cavada BS. J Struct Biol 154 280-286 (2006)
  10. How a plant lectin recognizes high mannose oligosaccharides. Garcia-Pino A, Buts L, Wyns L, Imberty A, Loris R. Plant Physiol 144 1733-1741 (2007)
  11. Mass spectrometric characterization of isoform variants of peanut (Arachis hypogaea) stem lectin (SL-I). Agrawal P, Kumar S, Das HR. J Proteomics 73 1573-1586 (2010)
  12. Interplay between metal binding and cis/trans isomerization in legume lectins: structural and thermodynamic study of P. angolensis lectin. Garcia-Pino A, Buts L, Wyns L, Loris R. J Mol Biol 361 153-167 (2006)
  13. Structural basis for the recognition of complex-type biantennary oligosaccharides by Pterocarpus angolensis lectin. Buts L, Garcia-Pino A, Imberty A, Amiot N, Boons GJ, Beeckmans S, Versées W, Wyns L, Loris R. FEBS J 273 2407-2420 (2006)
  14. Crystal structure of the lectin of Camptosema pedicellatum: implications of a conservative substitution at the hydrophobic subsite. Souza Teixeira C, da Silva HC, de Moura TR, Pereira-Júnior FN, do Nascimento KS, Nagano CS, Sampaio AH, Delatorre P, Rocha BA, Cavada BS. J Biochem 152 87-98 (2012)
  15. Purification and characterization of a mannose/N-acetyl-D-glucosamine-specific lectin from the seeds of Platymiscium floribundum Vogel. Pereira-Junior FN, Silva HC, Freitas BT, Rocha BA, Nascimento KS, Nagano CS, Leal RB, Sampaio AH, Cavada BS. J Mol Recognit 25 443-449 (2012)
  16. A Novel Integrated Way for Deciphering the Glycan Code for the FimH Lectin. Dumych T, Bridot C, Gouin SG, Lensink MF, Paryzhak S, Szunerits S, Blossey R, Bilyy R, Bouckaert J, Krammer EM. Molecules 23 E2794 (2018)
  17. Structural basis of carbohydrate recognition by a Man(alpha1-2)Man-specific lectin from Bowringia milbraedii. Buts L, Garcia-Pino A, Wyns L, Loris R. Glycobiology 16 635-640 (2006)
  18. Purification and molecular characterization of a novel mannose-specific lectin from Dioclea reflexa hook seeds with inflammatory activity. Pinto-Junior VR, Correia JL, Pereira RI, Pereira-Junior FN, Santiago MQ, Osterne VJ, Madeira JC, Cajazeiras JB, Nagano CS, Delatorre P, Assreuy AM, Nascimento KS, Cavada BS. J Mol Recognit 29 134-141 (2016)
  19. Purification and primary structure of a novel mannose-specific lectin from Centrolobium microchaete Mart seeds. Vasconcelos MA, Alves AC, Carneiro RF, Dias AH, Martins FW, Cajazeiras JB, Nagano CS, Teixeira EH, Nascimento KS, Cavada BS. Int J Biol Macromol 81 600-607 (2015)
  20. Partial characterization and immobilization in CNBr-activated Sepharose of a native lectin from Platypodium elegans seeds (PELa) and comparative study of edematogenic effect with the recombinant form. Araripe DA, Pinto-Junior VR, Neco AHB, Santiago MQ, Osterne VJS, Pires AF, Lossio CF, Martins MGQ, Correia JLA, Benevides RG, Leal RB, Assreuy AMS, Nascimento KS, Cavada BS. Int J Biol Macromol 102 323-330 (2017)
  21. Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors. Krammer EM, Bridot C, Serna S, Echeverria B, Semwal S, Roubinet B, van Noort K, Wilbers RHP, Bourenkov G, de Ruyck J, Landemarre L, Reichardt N, Bouckaert J. J Biol Chem 299 104627 (2023)
  22. Screening of mushrooms from the woodlands of Zimbabwe: Occurrence of lectins and partial purification of a mucin specific lectin from Boletus edulis. Reid T, Fore F, Chidzwondo F, Kashangura C, Stray-Pedersen B, Mduluza T. PLoS One 17 e0265494 (2022)
  23. cDNA cloning, molecular modeling and docking calculations of L-type lectins from Swartzia simplex var. grandiflora (Leguminosae, Papilionoideae), a member of the tribe Swartzieae. Maranhão PAC, Teixeira CS, Sousa BL, Barroso-Neto IL, Monteiro-Júnior JE, Fernandes AV, Ramos MV, Vasconcelos IM, Gonçalves JFC, Rocha BAM, Freire VN, Grangeiro TB. Phytochemistry 139 60-71 (2017)


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