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Structure of polyketide synthase associated protein 5 from Mycobacterium tuberculosis

Source organism: Mycobacterium tuberculosis
Biochemical function: acyltransferase activity, transferring groups other than amino-acyl groups
Biological process: DIM/DIP cell wall layer assembly
Cellular component: cytosol

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EC 2.3.1.282: Phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase

Reaction catalysed:
2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol = a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
Systematic name:
Mycocerosyl-[mycocerosic acid synthase]:phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF16911
Domain description: Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus
Occurring in:
  1. Phthiocerol/phthiodiolone dimycocerosyl transferase
The deposited structure of PDB entry 1q9j contains 2 copies of Pfam domain PF16911 (Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus) in Phthiocerol/phthiodiolone dimycocerosyl transferase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR031641
Domain description: Phthiocerol/phthiodiolone dimycocerosyl transferase, C-terminal
Occurring in:
  1. Phthiocerol/phthiodiolone dimycocerosyl transferase
IPR023213
Domain description: Chloramphenicol acetyltransferase-like domain superfamily
Occurring in:
  1. Phthiocerol/phthiodiolone dimycocerosyl transferase

Structure domains

CATH CATH domains
3.30.559.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Chloramphenicol Acetyltransferase
Homology: Nonribosomal peptide synthetase, condensation domain
Occurring in:
  1. Phthiocerol/phthiodiolone dimycocerosyl transferase
The deposited structure of PDB entry 1q9j contains 2 copies of CATH domain 3.30.559.30 (Chloramphenicol Acetyltransferase) in Phthiocerol/phthiodiolone dimycocerosyl transferase. Showing 1 copy in chain B.
3.30.559.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Chloramphenicol Acetyltransferase
Homology: Chloramphenicol acetyltransferase-like domain
Occurring in:
  1. Phthiocerol/phthiodiolone dimycocerosyl transferase
The deposited structure of PDB entry 1q9j contains 2 copies of CATH domain 3.30.559.10 (Chloramphenicol Acetyltransferase) in Phthiocerol/phthiodiolone dimycocerosyl transferase. Showing 1 copy in chain B.
SCOP SCOP annotation
75229
Class: Alpha and beta proteins (a/b)
Fold: CoA-dependent acyltransferases
Superfamily: CoA-dependent acyltransferases
Occurring in:
  1. Phthiocerol/phthiodiolone dimycocerosyl transferase
The deposited structure of PDB entry 1q9j contains 4 copies of SCOP domain 75229 (NRPS condensation domain (amide synthase)) in Phthiocerol/phthiodiolone dimycocerosyl transferase. Showing 2 copies in chain B.

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