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Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain

X-ray diffraction
2.1Å resolution
PDB entry 1qwt coloured by chain, front view.
PDB entry 1qwt coloured by chain, side view.
PDB entry 1qwt coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Interferon regulatory factor 3
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Multimeric state: homo dimer
Accessible surface area: 23306.85 Å2
Buried surface area: 2398.74 Å2
Dissociation area: 461.96 Å2
Dissociation energy (ΔGdiss): -5.96 kcal/mol
Dissociation entropy (TΔSdiss): 12.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172054

Macromolecules

Interferon regulatory factor 3
Chains: A, B
Length: 255 amino acids
Theoretical weight: 28.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14653 (Residues: 173-427; Coverage: 60%)
Gene name: IRF3
Pfam: Interferon-regulatory factor 3
InterPro:
CATH: Tumour Suppressor Smad4
SCOP: Interferon regulatory factor 3 (IRF3), transactivation domain
Interferon regulatory factor 3 in PDB entry 1qwt, assembly 1, front view.
Interferon regulatory factor 3 in PDB entry 1qwt, assembly 1, side view.
Interferon regulatory factor 3 in PDB entry 1qwt, assembly 1, top view.
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