Structure analysis

Human topoisomerase I (Topo70) double mutant K532R/Y723F

X-ray diffraction
3.13Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 35650.53 Å2
Buried surface area: 6008.67 Å2
Dissociation area: 2,037.75 Å2
Dissociation energy (ΔGdiss): 35.16 kcal/mol
Dissociation entropy (TΔSdiss): 13.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114494

Macromolecules

PDBe-KB: UniProt Coverage View: P11387  
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Name: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 22 nucleotides
Theoretical weight: 6.79 KDa
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Name: 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 22 nucleotides
Theoretical weight: 6.71 KDa
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