Assemblies
Assembly Name:
DNA topoisomerase 1 and DNA
Multimeric state:
hetero trimer
Accessible surface area:
35650.53 Å2
Buried surface area:
6008.67 Å2
Dissociation area:
2,037.75
Å2
Dissociation energy (ΔGdiss):
35.16
kcal/mol
Dissociation entropy (TΔSdiss):
13.17
kcal/mol
Symmetry number:
1
PDBe Complex ID:
PDB-CPX-114494
Macromolecules
Chain: A
Length: 592 amino acids
Theoretical weight: 70.18 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Pfam:
Length: 592 amino acids
Theoretical weight: 70.18 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P11387 (Residues: 174-765; Coverage: 77%)
Pfam:
- Eukaryotic DNA topoisomerase I, DNA binding fragment
- Eukaryotic DNA topoisomerase I, catalytic core
- C-terminal topoisomerase domain
- DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily
- DNA topoisomerase I, DNA binding, N-terminal domain 2
- DNA topoisomerase I, DNA binding, eukaryotic-type
- DNA topoisomerase I, DNA-binding domain
- DNA topoisomerase I, DNA binding, N-terminal domain 1
- DNA topoisomerase I
- DNA topoisomerase I, eukaryotic-type
- DNA breaking-rejoining enzyme, catalytic core
- DNA topoisomerase I, catalytic core, eukaryotic-type
- DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
- DNA topoisomerase I, catalytic core, alpha/beta subdomain
- Topoisomerase I C-terminal domain
- DNA Topoisomerase I, domain 2
- Yeast DNA topoisomerase - domain 1
- Topoisomerase I; Chain A, domain 3
- Topoisomerase I; Chain A, domain 4
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Name:
5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 22 nucleotides
Theoretical weight: 6.79 KDa
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 22 nucleotides
Theoretical weight: 6.79 KDa
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Name:
5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 22 nucleotides
Theoretical weight: 6.71 KDa
Representative chains: C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 22 nucleotides
Theoretical weight: 6.71 KDa
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