› 1r4k

Solution NMR

Solution Structure of the Drosophila Argonaute 1 PAZ Domain

Released:
DOI: 10.2210/pdb1r4k/pdb
PDB entry 1r4k coloured by chain, front view.
PDB entry 1r4k coloured by chain, side view.
PDB entry 1r4k coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure and conserved RNA binding of the PAZ domain.
Yan KS, Yan S, Farooq A, Han A, Zeng L, Zhou MM
Nature 426 468-74 (2003)
PMID: 14615802

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174283 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Argonaute-1, isoform A Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.8 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q32KD4 (Residues: 331-498; Coverage: 17%)
Gene names: AGO-1, AGO1, AGO1-RC, Ago, Ago-1, Ago1, Agp1, CG6671, Dm Ago1, DmAgo1, Dmel\CG6671, Dmel_CG6671, MRE20, ago1, ago1-1, anon-WO0257455.29, argonaute1, dAGO1, dAgo1, dmAgo1, l(2)04845, l(2)4845, l(2)k00208, l(2)k08121
Sequence domains:
Structure domains: paz domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

101 review citations

MicroRNAs: genomics, biogenesis, mechanism, and function.
Bartel DP. (2004)
100 more

3 mentions without citation

A Glimpse of "Dicer Biology" Through the Structural and Functional Perspective.
Paturi et al. (2021)
2 more