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Glycosyltransferase A in complex with 3-amino-acceptor analog inhibitor and uridine diphosphate-N-acetyl-galactose

X-ray diffraction
1.75Å resolution
PDB entry 1r81 coloured by chain, front view.
PDB entry 1r81 coloured by chain, side view.
PDB entry 1r81 coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form
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Multimeric state: monomeric
Accessible surface area: 13921.01 Å2
Buried surface area: 1891.86 Å2
Dissociation area: 345.14 Å2
Dissociation energy (ΔGdiss): -7.38 kcal/mol
Dissociation entropy (TΔSdiss): 4.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147725
Assembly 2
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Assembly Name: Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form
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Multimeric state: homo dimer
Accessible surface area: 22875.13 Å2
Buried surface area: 8752.23 Å2
Dissociation area: 2,484.05 Å2
Dissociation energy (ΔGdiss): 37.81 kcal/mol
Dissociation entropy (TΔSdiss): 13.77 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-147726

Macromolecules

Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form
Chain: A
Length: 283 amino acids
Theoretical weight: 33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16442 (Residues: 64-345; Coverage: 80%)
Gene name: ABO
Pfam: Glycosyltransferase family 6
InterPro:
CATH: Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
SCOP: alpha-1,3-galactosyltransferase-like
Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form in PDB entry 1r81, assembly 1, front view.
Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form in PDB entry 1r81, assembly 1, side view.
Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form in PDB entry 1r81, assembly 1, top view.
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