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Hydrolysis of ATP in the crystal of Y204A mutant of cAMP-dependent protein kinase

X-ray diffraction
1.26Å resolution
PDB entry 1rdq coloured by chain, front view.
PDB entry 1rdq coloured by chain, side view.
PDB entry 1rdq coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase catalytic subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 15199.1 Å2
Buried surface area: 4679.55 Å2
Dissociation area: 1,112.71 Å2
Dissociation energy (ΔGdiss): 9.49 kcal/mol
Dissociation entropy (TΔSdiss): 9.15 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138548

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: E
Length: 350 amino acids
Theoretical weight: 40.57 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P05132 (Residues: 2-351; Coverage: 100%)
Gene names: Pkaca, Prkaca
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 1rdq, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 1rdq, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 1rdq, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P05132  
135050100150200250300350
 
100200300
UniProt
P05132
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Secondary structure
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Ligand binding sites
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cAMP-dependent protein kinase inhibitor, alpha form
Chain: I
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Mus musculus
Expression system: Not provided
InterPro: cAMP-dependent protein kinase inhibitor
cAMP-dependent protein kinase inhibitor, alpha form in PDB entry 1rdq, assembly 1, front view.
cAMP-dependent protein kinase inhibitor, alpha form in PDB entry 1rdq, assembly 1, side view.
cAMP-dependent protein kinase inhibitor, alpha form in PDB entry 1rdq, assembly 1, top view.
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