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CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-Br-AMP

X-ray diffraction
2.13Å resolution
PDB entry 1ro9 coloured by chain, front view.
PDB entry 1ro9 coloured by chain, side view.
PDB entry 1ro9 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 3',5'-cyclic-AMP phosphodiesterase 4B
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Multimeric state: monomeric
Accessible surface area: 15214.52 Å2
Buried surface area: 1001.57 Å2
Dissociation area: 399.28 Å2
Dissociation energy (ΔGdiss): 18.03 kcal/mol
Dissociation entropy (TΔSdiss): 4.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170460
Assembly 2
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Assembly Name: 3',5'-cyclic-AMP phosphodiesterase 4B
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Multimeric state: monomeric
Accessible surface area: 15247.72 Å2
Buried surface area: 985.06 Å2
Dissociation area: 393.34 Å2
Dissociation energy (ΔGdiss): 20 kcal/mol
Dissociation entropy (TΔSdiss): 4.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170460

Macromolecules

3',5'-cyclic-AMP phosphodiesterase 4B
Chains: A, B
Length: 378 amino acids
Theoretical weight: 43.45 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q07343 (Residues: 324-700; Coverage: 51%)
Gene names: DPDE4, PDE4B
Pfam: 3'5'-cyclic nucleotide phosphodiesterase
InterPro:
CATH: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
SCOP: PDEase
3',5'-cyclic-AMP phosphodiesterase 4B in PDB entry 1ro9, assembly 1, front view.
3',5'-cyclic-AMP phosphodiesterase 4B in PDB entry 1ro9, assembly 1, side view.
3',5'-cyclic-AMP phosphodiesterase 4B in PDB entry 1ro9, assembly 1, top view.
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