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Enhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues

X-ray diffraction
1.8Å resolution
PDB entry 1rwe coloured by chain, front view.
PDB entry 1rwe coloured by chain, side view.
PDB entry 1rwe coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero hexamer (preferred)
hetero dodecamer
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1
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Assembly Name: Insulin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 10448.67 Å2
Buried surface area: 5111.25 Å2
Dissociation area: 187.59 Å2
Dissociation energy (ΔGdiss): 7.74 kcal/mol
Dissociation entropy (TΔSdiss): 20.3 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134224
Assembly 2 (preferred)
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Assembly Name: Insulin B chain
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Multimeric state: hetero hexamer
Accessible surface area: 9638.88 Å2
Buried surface area: 7059.26 Å2
Dissociation area: 2,658.24 Å2
Dissociation energy (ΔGdiss): 20.65 kcal/mol
Dissociation entropy (TΔSdiss): 26.29 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134224
Assembly 3
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Assembly Name: Insulin B chain
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Multimeric state: hetero dodecamer
Accessible surface area: 13636.99 Å2
Buried surface area: 18621.08 Å2
Dissociation area: 100.32 Å2
Dissociation energy (ΔGdiss): 26.99 kcal/mol
Dissociation entropy (TΔSdiss): 1.1 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-134235

Macromolecules

Insulin A chain
Chains: A, C
Length: 21 amino acids
Theoretical weight: 2.42 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
Insulin A chain in PDB entry 1rwe, assembly 2, front view.
Insulin A chain in PDB entry 1rwe, assembly 2, side view.
Insulin A chain in PDB entry 1rwe, assembly 2, top view.
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Insulin B chain
Chains: B, D
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
Insulin B chain in PDB entry 1rwe, assembly 2, front view.
Insulin B chain in PDB entry 1rwe, assembly 2, side view.
Insulin B chain in PDB entry 1rwe, assembly 2, top view.
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