› 1sac

X-ray diffraction
2Å resolution

THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT

Released:
DOI: 10.2210/pdb1sac/pdb
PDB entry 1sac coloured by chain, front view.
PDB entry 1sac coloured by chain, side view.
PDB entry 1sac coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of pentameric human serum amyloid P component.
Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP
Nature 367 338-45 (1994)
PMID: 8114934

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136123 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serum amyloid P-component Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 204 amino acids
Theoretical weight: 23.28 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02743 (Residues: 20-223; Coverage: 100%)
Gene names: APCS, PTX2
Sequence domains: Pentaxin family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand CA 10 x CA
Ligand ACY 4 x ACY
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 68.9Å b: 99.3Å c: 96.7Å
α: 90° β: 95.9° γ: 90°
R-values:
R R work R free
0.179 0.179 not available
Expression system: Not provided

Quick links

Citations

76 review citations

Innate immunity: impact on the adaptive immune response.
Medzhitov et al. (1997)
75 more

29 mentions without citation

Pentraxins in the activation and regulation of innate immunity.
Daigo et al. (2016)
28 more