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Caspase-7 in complex with DICA allosteric inhibitor

X-ray diffraction
2.8Å resolution
PDB entry 1shj coloured by chain, front view.
PDB entry 1shj coloured by chain, side view.
PDB entry 1shj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Caspase-7
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Multimeric state: homo dimer
Accessible surface area: 17370.79 Å2
Buried surface area: 4704.56 Å2
Dissociation area: 1,517.79 Å2
Dissociation energy (ΔGdiss): 23.59 kcal/mol
Dissociation entropy (TΔSdiss): 12.91 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-157233

Macromolecules

Caspase-7 subunit p20
Chains: A, B
Length: 262 amino acids
Theoretical weight: 29.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55210 (Residues: 50-303; Coverage: 84%)
Gene names: CASP7, MCH3
Pfam: Caspase domain
InterPro:
CATH: Rossmann fold
SCOP: Caspase catalytic domain
Caspase-7 subunit p20 in PDB entry 1shj, assembly 1, front view.
Caspase-7 subunit p20 in PDB entry 1shj, assembly 1, side view.
Caspase-7 subunit p20 in PDB entry 1shj, assembly 1, top view.
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