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Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase

X-ray diffraction
1.85Å resolution
PDB entry 1t15 coloured by chain, front view.
PDB entry 1t15 coloured by chain, side view.
PDB entry 1t15 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Breast cancer type 1 susceptibility protein and Fanconi anemia group J protein
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Multimeric state: hetero dimer
Accessible surface area: 11241.31 Å2
Buried surface area: 983.94 Å2
Dissociation area: 491.97 Å2
Dissociation energy (ΔGdiss): 2.46 kcal/mol
Dissociation entropy (TΔSdiss): 6.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153641

Macromolecules

Breast cancer type 1 susceptibility protein
Chain: A
Length: 214 amino acids
Theoretical weight: 24.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P38398 (Residues: 1646-1859; Coverage: 12%)
Gene names: BRCA1, RNF53
Pfam: BRCA1 C Terminus (BRCT) domain
InterPro:
CATH: BRCT domain
SCOP: BRCT domain
Breast cancer type 1 susceptibility protein in PDB entry 1t15, assembly 1, front view.
Breast cancer type 1 susceptibility protein in PDB entry 1t15, assembly 1, side view.
Breast cancer type 1 susceptibility protein in PDB entry 1t15, assembly 1, top view.
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Fanconi anemia group J protein
Chain: B
Length: 8 amino acids
Theoretical weight: 962 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9BX63 (Residues: 988-995; Coverage: 1%)
Gene names: BACH1, BRIP1, FANCJ
Fanconi anemia group J protein in PDB entry 1t15, assembly 1, front view.
Fanconi anemia group J protein in PDB entry 1t15, assembly 1, side view.
Fanconi anemia group J protein in PDB entry 1t15, assembly 1, top view.
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