› 1tpn

Solution NMR

SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE

Released:
DOI: 10.2210/pdb1tpn/pdb
PDB entry 1tpn coloured by chain, ensemble of 28 models, front view.
PDB entry 1tpn coloured by chain, ensemble of 28 models, side view.
PDB entry 1tpn coloured by chain, ensemble of 28 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance.
Downing AK, Driscoll PC, Harvey TS, Dudgeon TJ, Smith BO, Baron M, Campbell ID
J Mol Biol 225 821-33 (1992)
PMID: 1602484

Function and Biology Details

Reaction catalysed: 
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133299 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tissue-type plasminogen activator chain A Chain: A
Molecule details ›
Chain: A
Length: 50 amino acids
Theoretical weight: 6.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00750 (Residues: 36-85; Coverage: 9%)
Gene name: PLAT
Sequence domains: Fibronectin type I domain
Structure domains: Complement Module, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

10 review citations

Structure and distribution of modules in extracellular proteins.
Bork et al. (1996)
9 more

1 mention without citation

Topology independent protein structural alignment.
Dundas et al. (2007)