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Crystal Structure of UP1 Complexed With d(TTAGGGTTAG(2PR)G); A Human Telomeric Repeat Containing 2-aminopurine

X-ray diffraction
1.8Å resolution
PDB entry 1u1r coloured by chain, front view.
PDB entry 1u1r coloured by chain, side view.
PDB entry 1u1r coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct DNA molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed and DNA
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Multimeric state: hetero dimer
Accessible surface area: 12428.78 Å2
Buried surface area: 2059.27 Å2
Dissociation area: 780.87 Å2
Dissociation energy (ΔGdiss): -3.82 kcal/mol
Dissociation entropy (TΔSdiss): 9.98 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-114676

Macromolecules

Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed
Chain: A
Length: 196 amino acids
Theoretical weight: 22.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09651 (Residues: 1-196; Coverage: 53%)
Gene names: HNRNPA1, HNRPA1
Pfam: RNA recognition motif
InterPro:
CATH: Alpha-Beta Plaits
SCOP: Canonical RBD
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed in PDB entry 1u1r, assembly 1, front view.
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed in PDB entry 1u1r, assembly 1, side view.
Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed in PDB entry 1u1r, assembly 1, top view.
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DNA chain B
Name: 5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*(2PR)P*G)-3'
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 11 nucleotides
Theoretical weight: 3.45 KDa
5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*(2PR)P*G)-3' in PDB entry 1u1r, assembly 1, front view.
5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*(2PR)P*G)-3' in PDB entry 1u1r, assembly 1, side view.
5'-D(*TP*AP*GP*GP*GP*TP*TP*AP*GP*(2PR)P*G)-3' in PDB entry 1u1r, assembly 1, top view.
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