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Crystal structure of tt0168 from Thermus thermophilus HB8

Source organism: Thermus thermophilus
Biochemical function: metal ion binding
Biological process: fatty acid metabolic process
Cellular component: not assigned

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EC 6.2.1.3: Long-chain-fatty-acid--CoA ligase

Reaction catalysed:
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA
Systematic name:
Long-chain fatty acid:CoA ligase (AMP-forming)
Alternative Name(s):
  • ACS3
  • Acyl coenzyme A synthetase
  • Acyl-CoA ligase
  • Acyl-CoA synthetase
  • Acyl-activating enzyme
  • Acyl-coenzyme A ligase
  • Arachidonyl-CoA synthetase
  • FAA1
  • Fatty acid CoA ligase
  • Fatty acid elongase
  • Fatty acid thiokinase (long chain)
  • Fatty acyl-coenzyme A synthetase
  • LCFA synthetase
  • Lignoceroyl-CoA synthase
  • Long chain fatty acyl-CoA synthetase
  • Long-chain acyl CoA synthetase
  • Long-chain acyl-CoA synthetase I
  • Long-chain acyl-CoA synthetase II
  • Long-chain acyl-coenzyme A synthetase
  • Long-chain fatty acyl coenzyme A synthetase
  • Oleoyl-CoA synthetase
  • Palmitoyl coenzyme A synthetase
  • Palmitoyl-CoA ligase
  • Palmitoyl-CoA synthase
  • Pristanoyl-CoA synthetase
  • Stearoyl-CoA synthetase
  • Thiokinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF13193
Domain description: AMP-binding enzyme C-terminal domain
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase
The deposited structure of PDB entry 1v26 contains 2 copies of Pfam domain PF13193 (AMP-binding enzyme C-terminal domain) in Long-chain-fatty-acid--CoA ligase. Showing 1 copy in chain B.

PF00501
Domain description: AMP-binding enzyme
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase
The deposited structure of PDB entry 1v26 contains 2 copies of Pfam domain PF00501 (AMP-binding enzyme) in Long-chain-fatty-acid--CoA ligase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR025110
Domain description: AMP-binding enzyme, C-terminal domain
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase
IPR045851
Domain description: AMP-binding enzyme, C-terminal domain superfamily
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase
IPR020845
Domain description: AMP-binding, conserved site
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase
IPR000873
Domain description: AMP-dependent synthetase/ligase domain
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase
IPR042099
Domain description: ANL, N-terminal domain
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase

Structure domains

CATH CATH domains
3.30.300.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: GMP Synthetase; Chain A, domain 3
Homology: GMP Synthetase; Chain A, domain 3
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase
The deposited structure of PDB entry 1v26 contains 2 copies of CATH domain 3.30.300.30 (GMP Synthetase; Chain A, domain 3) in Long-chain-fatty-acid--CoA ligase. Showing 1 copy in chain B.
3.40.50.12780
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: N-terminal domain of ligase-like
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase
The deposited structure of PDB entry 1v26 contains 2 copies of CATH domain 3.40.50.12780 (Rossmann fold) in Long-chain-fatty-acid--CoA ligase. Showing 1 copy in chain B.
SCOP SCOP annotation
56802
Class: Multi-domain proteins (alpha and beta)
Fold: Acetyl-CoA synthetase-like
Superfamily: Acetyl-CoA synthetase-like
Occurring in:
  1. Long-chain-fatty-acid--CoA ligase
The deposited structure of PDB entry 1v26 contains 2 copies of SCOP domain 56802 (Acetyl-CoA synthetase-like) in Long-chain-fatty-acid--CoA ligase. Showing 1 copy in chain B.

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