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The crystal structures of the REP-1 protein in complex with C-terminally truncated Rab7 protein

X-ray diffraction
2.5Å resolution
PDB entry 1vg9 coloured by chain, front view.
PDB entry 1vg9 coloured by chain, side view.
PDB entry 1vg9 coloured by chain, top view.
Source organism: Rattus norvegicus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ras-related protein Rab-7a and Rab proteins geranylgeranyltransferase component A 1
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Multimeric state: hetero dimer
Accessible surface area: 29060.86 Å2
Buried surface area: 3691.69 Å2
Dissociation area: 1,063.96 Å2
Dissociation energy (ΔGdiss): -4.09 kcal/mol
Dissociation entropy (TΔSdiss): 12.86 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140685
Assembly 2
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Assembly Name: Ras-related protein Rab-7a and Rab proteins geranylgeranyltransferase component A 1
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Multimeric state: hetero dimer
Accessible surface area: 29569.2 Å2
Buried surface area: 3625.08 Å2
Dissociation area: 1,043.46 Å2
Dissociation energy (ΔGdiss): -1.77 kcal/mol
Dissociation entropy (TΔSdiss): 12.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140685
Assembly 3
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Assembly Name: Ras-related protein Rab-7a and Rab proteins geranylgeranyltransferase component A 1
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Multimeric state: hetero dimer
Accessible surface area: 28975.1 Å2
Buried surface area: 3555.01 Å2
Dissociation area: 993.56 Å2
Dissociation energy (ΔGdiss): -2.21 kcal/mol
Dissociation entropy (TΔSdiss): 12.84 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140685
Assembly 4
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Assembly Name: Ras-related protein Rab-7a and Rab proteins geranylgeranyltransferase component A 1
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Multimeric state: hetero dimer
Accessible surface area: 29564.4 Å2
Buried surface area: 3649.9 Å2
Dissociation area: 1,053.26 Å2
Dissociation energy (ΔGdiss): -1.88 kcal/mol
Dissociation entropy (TΔSdiss): 12.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140685

Macromolecules

Rab proteins geranylgeranyltransferase component A 1
Chains: A, C, E, G
Length: 650 amino acids
Theoretical weight: 72.62 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P37727 (Residues: 1-650; Coverage: 100%)
Gene names: Chm, Rep1
Pfam:
InterPro:
CATH:
SCOP:
Rab proteins geranylgeranyltransferase component A 1 in PDB entry 1vg9, assembly 1, front view.
Rab proteins geranylgeranyltransferase component A 1 in PDB entry 1vg9, assembly 1, side view.
Rab proteins geranylgeranyltransferase component A 1 in PDB entry 1vg9, assembly 1, top view.
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Ras-related protein Rab-7a
Chains: B, D, F, H
Length: 185 amino acids
Theoretical weight: 21.12 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09527 (Residues: 1-185; Coverage: 89%)
Gene names: Rab7, Rab7a
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins
Ras-related protein Rab-7a in PDB entry 1vg9, assembly 1, front view.
Ras-related protein Rab-7a in PDB entry 1vg9, assembly 1, side view.
Ras-related protein Rab-7a in PDB entry 1vg9, assembly 1, top view.
Molecule details ›

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