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ASV INTEGRASE CORE DOMAIN WITH ZN(II) COFACTORS

X-ray diffraction
1.95Å resolution
PDB entry 1vsh coloured by chain, front view.
PDB entry 1vsh coloured by chain, side view.
PDB entry 1vsh coloured by chain, top view.
Source organism: Rous sarcoma virus (strain Schmidt-Ruppin)
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Integrase
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Multimeric state: homo dimer
Accessible surface area: 14268.6 Å2
Buried surface area: 3152.63 Å2
Dissociation area: 847.91 Å2
Dissociation energy (ΔGdiss): 23.92 kcal/mol
Dissociation entropy (TΔSdiss): 12.03 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-131654

Macromolecules

Integrase
Chain: A
Length: 152 amino acids
Theoretical weight: 16.77 KDa
Source organism: Rous sarcoma virus (strain Schmidt-Ruppin)
Expression system: Escherichia coli
UniProt:
  • Canonical: O92956 (Residues: 1333-1479; Coverage: 9%)
Gene name: gag-pol
Pfam: Integrase core domain
InterPro:
CATH: Ribonuclease H-like superfamily/Ribonuclease H
SCOP: Retroviral integrase, catalytic domain
Integrase in PDB entry 1vsh, assembly 1, front view.
Integrase in PDB entry 1vsh, assembly 1, side view.
Integrase in PDB entry 1vsh, assembly 1, top view.
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