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Structure of the tetramerization domain of acetylcholinesterase: four-fold interaction of a WWW motif with a left-handed polyproline helix

X-ray diffraction
2.35Å resolution
PDB entry 1vzj coloured by chain, front view.
PDB entry 1vzj coloured by chain, side view.
PDB entry 1vzj coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Acetylcholinesterase collagenic tail peptide and Acetylcholinesterase
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Multimeric state: hetero pentamer
Accessible surface area: 7948.95 Å2
Buried surface area: 7434.31 Å2
Dissociation area: 1,216.08 Å2
Dissociation energy (ΔGdiss): 13.22 kcal/mol
Dissociation entropy (TΔSdiss): 9.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149586
Assembly 2
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Assembly Name: Acetylcholinesterase collagenic tail peptide and Acetylcholinesterase
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Multimeric state: hetero pentamer
Accessible surface area: 8659.79 Å2
Buried surface area: 7244.58 Å2
Dissociation area: 1,104.3 Å2
Dissociation energy (ΔGdiss): 12.98 kcal/mol
Dissociation entropy (TΔSdiss): 9.76 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149586

Macromolecules

Acetylcholinesterase
Chains: A, B, C, D, E, F, G, H
Length: 40 amino acids
Theoretical weight: 5.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P22303 (Residues: 575-614; Coverage: 7%)
Gene name: ACHE
Pfam: Acetylcholinesterase tetramerisation domain
InterPro: Acetylcholinesterase, tetramerisation domain
Acetylcholinesterase in PDB entry 1vzj, assembly 1, front view.
Acetylcholinesterase in PDB entry 1vzj, assembly 1, side view.
Acetylcholinesterase in PDB entry 1vzj, assembly 1, top view.
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Acetylcholinesterase collagenic tail peptide
Chains: I, J
Length: 15 amino acids
Theoretical weight: 1.68 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q9Y215 (Residues: 53-67; Coverage: 4%)
Gene name: COLQ
Acetylcholinesterase collagenic tail peptide in PDB entry 1vzj, assembly 1, front view.
Acetylcholinesterase collagenic tail peptide in PDB entry 1vzj, assembly 1, side view.
Acetylcholinesterase collagenic tail peptide in PDB entry 1vzj, assembly 1, top view.
Molecule details ›

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