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Crystal structure of human cytochrome P450 3A4

X-ray diffraction
2.73Å resolution
PDB entry 1w0g coloured by chain, front view.
PDB entry 1w0g coloured by chain, side view.
PDB entry 1w0g coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytochrome P450 3A4
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Multimeric state: monomeric
Accessible surface area: 19465.15 Å2
Buried surface area: 1859.34 Å2
Dissociation area: 344.4 Å2
Dissociation energy (ΔGdiss): -2.98 kcal/mol
Dissociation entropy (TΔSdiss): 3.27 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140289

Macromolecules

Cytochrome P450 3A4
Chain: A
Length: 485 amino acids
Theoretical weight: 55.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08684 (Residues: 25-503; Coverage: 95%)
Gene names: CYP3A3, CYP3A4
Pfam: Cytochrome P450
InterPro:
CATH: Cytochrome P450
SCOP: Cytochrome P450
Cytochrome P450 3A4 in PDB entry 1w0g, assembly 1, front view.
Cytochrome P450 3A4 in PDB entry 1w0g, assembly 1, side view.
Cytochrome P450 3A4 in PDB entry 1w0g, assembly 1, top view.
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