› 1wzy

X-ray diffraction
2.5Å resolution

Crystal structure of human ERK2 complexed with a pyrazolopyridazine derivative

Released:
DOI: 10.2210/pdb1wzy/pdb
PDB entry 1wzy coloured by chain, front view.
PDB entry 1wzy coloured by chain, side view.
PDB entry 1wzy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative.
Kinoshita T, Warizaya M, Ohori M, Sato K, Neya M, Fujii T
Bioorg Med Chem Lett 16 55-8 (2006)
PMID: 16242327

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 368 amino acids
Theoretical weight: 42.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand F29 1 x F29
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: P21
Unit cell:
a: 48.599Å b: 68.541Å c: 59.833Å
α: 90° β: 110.27° γ: 90°
R-values:
R R work R free
0.253 0.249 0.292
Expression system: Escherichia coli

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Citations

1 review citation

Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.
Mazanetz et al. (2007)
15 other articles

7 mentions without citation

A chemical genetic approach demonstrates that MPK3/MPK6 activation and NADPH oxidase-mediated oxidative burst are two independent signaling events in plant immunity.
Xu et al. (2014)
6 more