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Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative.

Kinoshita T, Warizaya M, Ohori M, Sato K, Neya M, Fujii T
Bioorg Med Chem Lett 16 55-8 (2006)
Cited: 23 times
EuropePMC logo PMID: 16242327

Abstract

A series of pyrazolopyridazine compounds were briefly investigated as ERK2 inhibitors. The crystal structure of ERK2 complexed with an allyl derivative was determined. The compound induces structural change including movement of the glycine-rich loop and peptide flip between Met108-Glu109. As a result, the newly formed subsite can recognize small hydrophobic substituents but not hydrophilic ones.

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  2. Serotyping Streptococcus pneumoniae by multiplex PCR. Brito DA, Ramirez M, de Lencastre H. J Clin Microbiol 41 2378-2384 (2003)
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