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Structure of C5a peptidase- a key virulence factor from Streptococcus

Source organism: Streptococcus pyogenes
Biochemical function: serine-type peptidase activity
Biological process: proteolysis
Cellular component: membrane

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EC 3.4.21.110: C5a peptidase

Reaction catalysed:
The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59
Systematic name:
-
Alternative Name(s):
  • SCP
  • SCPA
  • ScpA
  • ScpB
  • Streptococcal C5a peptidase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF22143
Domain description: C5a peptidase, fibronectin type III domain
Occurring in:
  1. C5a peptidase

PF13585
Domain description: CHU_C Type IX secretion signal domain
Occurring in:
  1. C5a peptidase
The deposited structure of PDB entry 1xf1 contains 2 copies of Pfam domain PF13585 (CHU_C Type IX secretion signal domain) in C5a peptidase. Showing 1 copy in chain A.

PF06280
Domain description: Fn3-like domain
Occurring in:
  1. C5a peptidase
The deposited structure of PDB entry 1xf1 contains 2 copies of Pfam domain PF06280 (Fn3-like domain) in C5a peptidase. Showing 1 copy in chain A.

PF02225
Domain description: PA domain
Occurring in:
  1. C5a peptidase
The deposited structure of PDB entry 1xf1 contains 2 copies of Pfam domain PF02225 (PA domain) in C5a peptidase. Showing 1 copy in chain A.

PF00082
Domain description: Subtilase family
Occurring in:
  1. C5a peptidase
The deposited structure of PDB entry 1xf1 contains 2 copies of Pfam domain PF00082 (Subtilase family) in C5a peptidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR015500
Domain description: Peptidase S8, subtilisin-related
Occurring in:
  1. C5a peptidase
IPR036852
Domain description: Peptidase S8/S53 domain superfamily
Occurring in:
  1. C5a peptidase
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. C5a peptidase
IPR010435
Domain description: C5a peptidase/Subtilisin-like protease SBT2-like, Fn3-like domain
Occurring in:
  1. C5a peptidase
IPR023828
Domain description: Peptidase S8, subtilisin, Ser-active site
Occurring in:
  1. C5a peptidase
IPR003137
Domain description: PA domain
Occurring in:
  1. C5a peptidase
IPR046450
Domain description: PA domain superfamily
Occurring in:
  1. C5a peptidase
IPR022398
Domain description: Peptidase S8, subtilisin, His-active site
Occurring in:
  1. C5a peptidase
IPR023827
Domain description: Peptidase S8, subtilisin, Asp-active site
Occurring in:
  1. C5a peptidase
IPR000209
Domain description: Peptidase S8/S53 domain
Occurring in:
  1. C5a peptidase
IPR034216
Domain description: C5a peptidase-like domain
Occurring in:
  1. C5a peptidase

Structure domains

CATH CATH domains
3.40.50.200
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Peptidase S8/S53 domain
Occurring in:
  1. C5a peptidase
The deposited structure of PDB entry 1xf1 contains 2 copies of CATH domain 3.40.50.200 (Rossmann fold) in C5a peptidase. Showing 1 copy in chain A.
3.50.30.30
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: Glucose Oxidase; domain 1
Homology: Glucose Oxidase; domain 1
Occurring in:
  1. C5a peptidase
The deposited structure of PDB entry 1xf1 contains 2 copies of CATH domain 3.50.30.30 (Glucose Oxidase; domain 1) in C5a peptidase. Showing 1 copy in chain A.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. C5a peptidase
The deposited structure of PDB entry 1xf1 contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in C5a peptidase. Showing 1 copy in chain A.
2.60.40.1710
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Subtilisin-like superfamily
Occurring in:
  1. C5a peptidase
The deposited structure of PDB entry 1xf1 contains 2 copies of CATH domain 2.60.40.1710 (Immunoglobulin-like) in C5a peptidase. Showing 1 copy in chain A.

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