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Structure of C5a peptidase- a key virulence factor from Streptococcus

X-ray diffraction
1.9Å resolution
PDB entry 1xf1 coloured by chain, front view.
PDB entry 1xf1 coloured by chain, side view.
PDB entry 1xf1 coloured by chain, top view.
Source organism: Streptococcus pyogenes
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: C5a peptidase
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Multimeric state: homo dimer
Accessible surface area: 76420.78 Å2
Buried surface area: 9328.38 Å2
Dissociation area: 3,203.84 Å2
Dissociation energy (ΔGdiss): 18.43 kcal/mol
Dissociation entropy (TΔSdiss): 16.81 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-147541

Macromolecules

C5a peptidase
Chains: A, B
Length: 926 amino acids
Theoretical weight: 103 KDa
Source organism: Streptococcus pyogenes
Expression system: Escherichia coli
UniProt:
  • Canonical: P15926 (Residues: 106-1031; Coverage: 82%)
Gene name: scpA
Pfam:
InterPro:
CATH:
C5a peptidase in PDB entry 1xf1, assembly 1, front view.
C5a peptidase in PDB entry 1xf1, assembly 1, side view.
C5a peptidase in PDB entry 1xf1, assembly 1, top view.
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