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Structure of a human A-type Potassium Channel Accelerating factor DPPX, a member of the dipeptidyl aminopeptidase family

X-ray diffraction
3Å resolution
PDB entry 1xfd coloured by chain, front view.
PDB entry 1xfd coloured by chain, side view.
PDB entry 1xfd coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: A-type potassium channel modulatory protein DPP6
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Multimeric state: homo dimer
Accessible surface area: 62362.63 Å2
Buried surface area: 10529.53 Å2
Dissociation area: 1,874.84 Å2
Dissociation energy (ΔGdiss): 5.17 kcal/mol
Dissociation entropy (TΔSdiss): 15.7 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154838
Assembly 2
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Assembly Name: A-type potassium channel modulatory protein DPP6
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Multimeric state: homo dimer
Accessible surface area: 61177.43 Å2
Buried surface area: 9611.61 Å2
Dissociation area: 1,858.44 Å2
Dissociation energy (ΔGdiss): 4.13 kcal/mol
Dissociation entropy (TΔSdiss): 15.68 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-154838

Macromolecules

A-type potassium channel modulatory protein DPP6
Chains: A, B, C, D
Length: 723 amino acids
Theoretical weight: 82.83 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P42658 (Residues: 127-849; Coverage: 84%)
Gene name: DPP6
Pfam:
InterPro:
CATH:
SCOP:
A-type potassium channel modulatory protein DPP6 in PDB entry 1xfd, assembly 1, front view.
A-type potassium channel modulatory protein DPP6 in PDB entry 1xfd, assembly 1, side view.
A-type potassium channel modulatory protein DPP6 in PDB entry 1xfd, assembly 1, top view.
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