› 1xiy

X-ray diffraction
1.8Å resolution

Crystal Structure of Plasmodium falciparum antioxidant protein (1-Cys peroxiredoxin)

Released:
DOI: 10.2210/pdb1xiy/pdb
PDB entry 1xiy coloured by chain, front view.
PDB entry 1xiy coloured by chain, side view.
PDB entry 1xiy coloured by chain, top view.
Source organism: Plasmodium falciparum
Primary publication:
Crystal structure of a novel Plasmodium falciparum 1-Cys peroxiredoxin.
Sarma GN, Nickel C, Rahlfs S, Fischer M, Becker K, Karplus PA
J Mol Biol 346 1021-34 (2005)
PMID: 15701514

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177624 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Redoxin domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 182 amino acids
Theoretical weight: 21.36 KDa
Source organism: Plasmodium falciparum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5MYR6 (Residues: 59-240; Coverage: 83%)
Gene names: PF3D7_0729200, prx
Sequence domains: Redoxin
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
1 modified residue:
Ligand OCS 2 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2, ALS BEAMLINE 8.2.1, RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 42.49Å b: 79.77Å c: 108.51Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.187 0.218
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin.
Knoops et al. (2011)
10 more

8 mentions without citation

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Hall et al. (2011)
7 more