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Crystal structure analysis of sialic acid synthase (NeuB)from Neisseria meningitidis, bound to Mn2+, Phosphoenolpyruvate, and N-acetyl mannosaminitol

Source organism: Neisseria meningitidis
Biochemical function: metal ion binding
Biological process: carbohydrate biosynthetic process
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF08666
Domain description: SAF domain
Occurring in:
  1. AFP-like domain-containing protein
The deposited structure of PDB entry 1xuz contains 1 copy of Pfam domain PF08666 (SAF domain) in AFP-like domain-containing protein. Showing 1 copy in chain A.

PF03102
Domain description: NeuB family
Occurring in:
  1. AFP-like domain-containing protein
The deposited structure of PDB entry 1xuz contains 1 copy of Pfam domain PF03102 (NeuB family) in AFP-like domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR013974
Domain description: SAF domain
Occurring in:
  1. AFP-like domain-containing protein
IPR006190
Domain description: Antifreeze-like/N-acetylneuraminic acid synthase C-terminal
Occurring in:
  1. AFP-like domain-containing protein
IPR036732
Domain description: Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain superfamily
Occurring in:
  1. AFP-like domain-containing protein
IPR013132
Domain description: N-acetylneuraminic acid synthase, N-terminal
Occurring in:
  1. AFP-like domain-containing protein
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. AFP-like domain-containing protein

Structure domains

CATH CATH domains
3.90.1210.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Type Iii Antifreeze Protein Isoform Hplc 12
Homology: Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain
Occurring in:
  1. AFP-like domain-containing protein
The deposited structure of PDB entry 1xuz contains 1 copy of CATH domain 3.90.1210.10 (Type Iii Antifreeze Protein Isoform Hplc 12) in AFP-like domain-containing protein. Showing 1 copy in chain A.
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. AFP-like domain-containing protein
The deposited structure of PDB entry 1xuz contains 1 copy of CATH domain 3.20.20.70 (TIM Barrel) in AFP-like domain-containing protein. Showing 1 copy in chain A.
SCOP SCOP annotations
51270
Class: All beta proteins
Fold: beta-clip
Superfamily: AFP III-like domain
Occurring in:
  1. AFP-like domain-containing protein
The deposited structure of PDB entry 1xuz contains 1 copy of SCOP domain 51270 (AFP III-like domain) in AFP-like domain-containing protein. Showing 1 copy in chain A.
110368
Class: Alpha and beta proteins (a/b)
Fold: TIM beta/alpha-barrel
Superfamily: Aldolase
Occurring in:
  1. AFP-like domain-containing protein
The deposited structure of PDB entry 1xuz contains 1 copy of SCOP domain 110368 (NeuB-like) in AFP-like domain-containing protein. Showing 1 copy in chain A.

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