› 1y7k

Solution NMR

NMR structure family of Human Agouti Signalling Protein (80-132: Q115Y, S124Y)

Released:
DOI: 10.2210/pdb1y7k/pdb
PDB entry 1y7k coloured by chain, ensemble of 21 models, front view.
PDB entry 1y7k coloured by chain, ensemble of 21 models, side view.
PDB entry 1y7k coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the agouti signaling protein.
McNulty JC, Jackson PJ, Thompson DA, Chai B, Gantz I, Barsh GS, Dawson PE, Millhauser GL
J Mol Biol 346 1059-70 (2005)
PMID: 15701517

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154498 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Agouti-signaling protein Chain: A
Molecule details ›
Chain: A
Length: 53 amino acids
Theoretical weight: 5.82 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P42127 (Residues: 80-132; Coverage: 48%)
Gene names: AGTI, AGTIL, ASIP, ASP
Sequence domains: Agouti protein
Structure domains: Agouti domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Refinement method: simulated annealing / torsion angle dynamics
Expression system: Not provided

Quick links

Citations

9 review citations

Melanocortin 1 Receptor: Structure, Function, and Regulation.
Wolf Horrell et al. (2016)
8 more

2 mentions without citation

Molecular and functional analysis of human β-defensin 3 action at melanocortin receptors.
Nix et al. (2013)
1 more