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Solution Structure of matrix metalloproteinase 12 (MMP12) in the presence of N-Isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH)

Solution NMR
PDB entry 1ycm coloured by chain, ensemble of 20 models, front view.
PDB entry 1ycm coloured by chain, ensemble of 20 models, side view.
PDB entry 1ycm coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Macrophage metalloelastase
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Multimeric state: monomeric
Accessible surface area: 8894.48 Å2
Buried surface area: 858.78 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-153971

Macromolecules

Macrophage metalloelastase
Chain: A
Length: 159 amino acids
Theoretical weight: 17.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P39900 (Residues: 106-263; Coverage: 35%)
Gene names: HME, MMP12
Pfam: Matrixin
InterPro:
CATH: Collagenase (Catalytic Domain)
SCOP: Matrix metalloproteases, catalytic domain
Macrophage metalloelastase in PDB entry 1ycm, assembly 1, front view.
Macrophage metalloelastase in PDB entry 1ycm, assembly 1, side view.
Macrophage metalloelastase in PDB entry 1ycm, assembly 1, top view.
PDBe-KB: UniProt Coverage View: P39900  
115920406080100120140
 
50100150
UniProt
P39900
Chains
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Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
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