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Crystal structure of skeletal muscle troponin in the Ca2+-activated state

X-ray diffraction
3Å resolution
PDB entry 1ytz coloured by chain, front view.
PDB entry 1ytz coloured by chain, side view.
PDB entry 1ytz coloured by chain, top view.
Source organism: Gallus gallus
Assemblies composition:
hetero trimer (preferred)
hetero hexamer
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 24928.79 Å2
Buried surface area: 11430.5 Å2
Dissociation area: 2,785.59 Å2
Dissociation energy (ΔGdiss): 29.56 kcal/mol
Dissociation entropy (TΔSdiss): 13.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135943
Assembly 2
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Multimeric state: hetero hexamer
Accessible surface area: 46785.64 Å2
Buried surface area: 25948.29 Å2
Dissociation area: 1,560.97 Å2
Dissociation energy (ΔGdiss): 6.55 kcal/mol
Dissociation entropy (TΔSdiss): 14.98 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-135945

Macromolecules

Troponin T, fast skeletal muscle isoforms
Chain: T
Length: 107 amino acids
Theoretical weight: 12.69 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12620 (Residues: 157-263; Coverage: 41%)
Gene name: TNNT3
Pfam: Troponin
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Troponin T
Troponin T, fast skeletal muscle isoforms in PDB entry 1ytz, assembly 1, front view.
Troponin T, fast skeletal muscle isoforms in PDB entry 1ytz, assembly 1, side view.
Troponin T, fast skeletal muscle isoforms in PDB entry 1ytz, assembly 1, top view.
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Troponin I, fast skeletal muscle
Chain: I
Length: 182 amino acids
Theoretical weight: 21.12 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P68246 (Residues: 2-183; Coverage: 100%)
Gene name: TNNI2
Pfam: Troponin
InterPro:
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
SCOP: Troponin I
Troponin I, fast skeletal muscle in PDB entry 1ytz, assembly 1, front view.
Troponin I, fast skeletal muscle in PDB entry 1ytz, assembly 1, side view.
Troponin I, fast skeletal muscle in PDB entry 1ytz, assembly 1, top view.
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Troponin C, skeletal muscle
Chain: C
Length: 162 amino acids
Theoretical weight: 18.26 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02588 (Residues: 2-163; Coverage: 99%)
Gene name: TNNC2
Pfam:
InterPro:
CATH: EF-hand
SCOP: Calmodulin-like
Troponin C, skeletal muscle in PDB entry 1ytz, assembly 1, front view.
Troponin C, skeletal muscle in PDB entry 1ytz, assembly 1, side view.
Troponin C, skeletal muscle in PDB entry 1ytz, assembly 1, top view.
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