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Crystal structure of the human Notch 1 ankyrin domain

X-ray diffraction
1.901Å resolution
PDB entry 1yyh coloured by chain, front view.
PDB entry 1yyh coloured by chain, side view.
PDB entry 1yyh coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Neurogenic locus notch homolog protein 1
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Multimeric state: monomeric
Accessible surface area: 9241.44 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155479
Assembly 2
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Assembly Name: Neurogenic locus notch homolog protein 1
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Multimeric state: monomeric
Accessible surface area: 9032.28 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155479

Macromolecules

Notch 1 intracellular domain
Chains: A, B
Length: 253 amino acids
Theoretical weight: 27.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46531 (Residues: 1872-2114; Coverage: 10%)
Gene names: NOTCH1, TAN1
Pfam:
InterPro:
CATH: Ankyrin repeat-containing domain
Notch 1 intracellular domain in PDB entry 1yyh, assembly 1, front view.
Notch 1 intracellular domain in PDB entry 1yyh, assembly 1, side view.
Notch 1 intracellular domain in PDB entry 1yyh, assembly 1, top view.
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