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Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition

X-ray diffraction
2.25Å resolution
PDB entry 1z3u coloured by chain, front view.
PDB entry 1z3u coloured by chain, side view.
PDB entry 1z3u coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Angiopoietin-2
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-127303
Assembly 2
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Assembly Name: Angiopoietin-2
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-127303
Assembly 3
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Assembly Name: Angiopoietin-2
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-127303
Assembly 4
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Assembly Name: Angiopoietin-2
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-127303

Macromolecules

Angiopoietin-2
Chains: A, B, C, D
Length: 217 amino acids
Theoretical weight: 24.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15123 (Residues: 281-496; Coverage: 45%)
Gene name: ANGPT2
Pfam: Fibrinogen beta and gamma chains, C-terminal globular domain
InterPro:
CATH:
Angiopoietin-2 in PDB entry 1z3u, assembly 1, front view.
Angiopoietin-2 in PDB entry 1z3u, assembly 1, side view.
Angiopoietin-2 in PDB entry 1z3u, assembly 1, top view.
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