› 1z3u

X-ray diffraction
2.25Å resolution

Structure of the Angiopoietin-2 Recptor Binding Domain and Identification of Surfaces Involved in Tie2 Recognition

Released:
DOI: 10.2210/pdb1z3u/pdb
PDB entry 1z3u coloured by chain, front view.
PDB entry 1z3u coloured by chain, side view.
PDB entry 1z3u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the angiopoietin-2 receptor binding domain and identification of surfaces involved in Tie2 recognition.
Barton WA, Tzvetkova D, Nikolov DB
Structure 13 825-32 (2005)
PMID: 15893672

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiopoietin-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 217 amino acids
Theoretical weight: 24.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15123 (Residues: 281-496; Coverage: 45%)
Gene name: ANGPT2
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: C2
Unit cell:
a: 140.218Å b: 94.468Å c: 84.673Å
α: 90° β: 94.47° γ: 90°
R-values:
R R work R free
0.26 0.246 0.278
Expression system: Escherichia coli

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Citations

11 review citations

The role of monocytes in angiogenesis and atherosclerosis.
Jaipersad et al. (2014)
10 more