› 2d4e

X-ray diffraction
2.1Å resolution

Crystal Structure of the HpcC from Thermus Thermophilus HB8

Released:
DOI: 10.2210/pdb2d4e/pdb
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PDB entry 2d4e coloured by chain, front view.
PDB entry 2d4e coloured by chain, side view.
PDB entry 2d4e coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Entry authors: Mizutani H, Kunishima N, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
5-carboxymethyl-2-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 5-carboxymethyl-2-hydroxymuconate + NADH
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178033 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aldehyde dehydrogenase domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 515 amino acids
Theoretical weight: 57.28 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5SJP9 (Residues: 1-515; Coverage: 100%)
Gene name: TTHA0959
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
2 bound ligands:
Ligand NA 6 x NA
Ligand GOL 3 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: P1
Unit cell:
a: 95.202Å b: 95.086Å c: 98.835Å
α: 103.97° β: 116.11° γ: 104.44°
R-values:
R R work R free
0.181 0.179 0.212
Expression system: Escherichia coli BL21(DE3)

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