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Crystal Structure of the HpcC from Thermus Thermophilus HB8

X-ray diffraction
2.1Å resolution
PDB entry 2d4e coloured by chain, front view.
PDB entry 2d4e coloured by chain, side view.
PDB entry 2d4e coloured by chain, top view.
Source organism: Thermus thermophilus HB8
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aldehyde dehydrogenase domain-containing protein
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Multimeric state: homo tetramer
Accessible surface area: 63692.4 Å2
Buried surface area: 26497.85 Å2
Dissociation area: 4,029.3 Å2
Dissociation energy (ΔGdiss): 41 kcal/mol
Dissociation entropy (TΔSdiss): 16.65 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-178033
Homo tetrameric assembly 1 of PDB entry 2d4e coloured by chemically distinct molecules, front view.
Homo tetrameric assembly 1 of PDB entry 2d4e coloured by chemically distinct molecules, side view.
Homo tetrameric assembly 1 of PDB entry 2d4e coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 4
Symmetry : D2
More details
3DComplex & QSbio predictionx
No. subunits : 4
Symmetry : D2
Evidence : Interface geometry is similar to that of 3n80_1 (42% id)

Macromolecules

Aldehyde dehydrogenase domain-containing protein
Chains: A, B, C, D
Length: 515 amino acids
Theoretical weight: 57.28 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5SJP9 (Residues: 1-515; Coverage: 100%)
Gene name: TTHA0959
Pfam: Aldehyde dehydrogenase family
InterPro:
CATH:
Aldehyde dehydrogenase domain-containing protein in PDB entry 2d4e, assembly 1, front view.
Aldehyde dehydrogenase domain-containing protein in PDB entry 2d4e, assembly 1, side view.
Aldehyde dehydrogenase domain-containing protein in PDB entry 2d4e, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q5SJP9  
151550100150200250300350400450500
 
200400MRYADRVAGISWETIEEVRRRLKERPALHFIAGEFVPSESGETFPSLDPATNEVLGVAARGGEREVDRAAKAAHEAFQRWSRTKAKERKRYLLRIAELIEKHADELAVMECLDAGQVLRIVRAQVARAAENFAFYAEYAEHAMEDRTFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLKPAEWSPFTATKLAEILKEADLPPGVFNLVQGFGEEAGAALVAHPLVPLLTLTGETETGKIVMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEKIFEDFVGKVVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVGENHMKIAQEEIFGPVLVAIPFKDEEEALRKANDTKYGLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLPTPFGGVKGSGDRREGGTYALDFYTDLKTIALPLRPPHVPKFGK
UniProt
Q5SJP9
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Ligand binding sites
Interaction interfaces
Sequence conservation
Molecule details ›

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