› 2oqp

Solution NMR

Solution structure of human interleukin-21

Released:
DOI: 10.2210/pdb2oqp/pdb
PDB entry 2oqp coloured by chain, ensemble of 20 models, front view.
PDB entry 2oqp coloured by chain, ensemble of 20 models, side view.
PDB entry 2oqp coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue.
Bondensgaard K, Breinholt J, Madsen D, Omkvist DH, Kang L, Worsaae A, Becker P, Schiødt CB, Hjorth SA
J Biol Chem 282 23326-36 (2007)
PMID: 17565991

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-574525 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-21 Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli str. K-12 substr. W3110
UniProt:
  • Canonical: Q9HBE4 (Residues: 30-162; Coverage: 96%)
Gene name: IL21
Sequence domains: Interleukin 15
Structure domains: Interleukin-15/Interleukin-21

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli str. K-12 substr. W3110

Quick links

Citations

4 review citations

Interleukin-21: basic biology and implications for cancer and autoimmunity.
Spolski et al. (2008)
3 more

5 mentions without citation

Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R.
Hamming et al. (2012)
4 more