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Crystal Structure of Foxp2 bound Specifically to DNA.

X-ray diffraction
1.9Å resolution
PDB entry 2a07 coloured by chain, front view.
PDB entry 2a07 coloured by chain, side view.
PDB entry 2a07 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero decamer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Forkhead box protein P2 and DNA
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Multimeric state: hetero decamer
Accessible surface area: 40642.72 Å2
Buried surface area: 19980.96 Å2
Dissociation area: 652.26 Å2
Dissociation energy (ΔGdiss): -1.88 kcal/mol
Dissociation entropy (TΔSdiss): 14.07 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-115056

Macromolecules

Forkhead box protein P2
Chains: F, G, H, I, J, K
Length: 93 amino acids
Theoretical weight: 11.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15409 (Residues: 502-594; Coverage: 13%)
Gene names: CAGH44, FOXP2, TNRC10
Pfam: Forkhead domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
SCOP: Forkhead DNA-binding domain
Forkhead box protein P2 in PDB entry 2a07, assembly 1, front view.
Forkhead box protein P2 in PDB entry 2a07, assembly 1, side view.
Forkhead box protein P2 in PDB entry 2a07, assembly 1, top view.
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DNA chains A, C
Name: 5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3'
Representative chains: A, C
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.39 KDa
5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3' in PDB entry 2a07, assembly 1, front view.
5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3' in PDB entry 2a07, assembly 1, side view.
5'-D(*AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*T)-3' in PDB entry 2a07, assembly 1, top view.
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DNA chains B, D
Name: 5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3'
Representative chains: B, D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 21 nucleotides
Theoretical weight: 6.49 KDa
5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3' in PDB entry 2a07, assembly 1, front view.
5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3' in PDB entry 2a07, assembly 1, side view.
5'-D(*TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*G)-3' in PDB entry 2a07, assembly 1, top view.
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