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Crystal Structure of the Catalytic Domain of Human Tyrosine Phosphatase Receptor, Type R

X-ray diffraction
2.3Å resolution
PDB entry 2a8b coloured by chain, front view.
PDB entry 2a8b coloured by chain, side view.
PDB entry 2a8b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Receptor-type tyrosine-protein phosphatase R
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Multimeric state: monomeric
Accessible surface area: 12725.77 Å2
Buried surface area: 100.43 Å2
Dissociation area: 50.21 Å2
Dissociation energy (ΔGdiss): 7.34 kcal/mol
Dissociation entropy (TΔSdiss): -0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172237

Macromolecules

Receptor-type tyrosine-protein phosphatase R
Chain: A
Length: 283 amino acids
Theoretical weight: 32.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15256 (Residues: 375-655; Coverage: 44%)
Gene names: ECPTP, PTPRQ, PTPRR
Pfam: Protein-tyrosine phosphatase
InterPro:
CATH: Protein tyrosine phosphatase superfamily
Receptor-type tyrosine-protein phosphatase R in PDB entry 2a8b, assembly 1, front view.
Receptor-type tyrosine-protein phosphatase R in PDB entry 2a8b, assembly 1, side view.
Receptor-type tyrosine-protein phosphatase R in PDB entry 2a8b, assembly 1, top view.
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