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Mineralocorticoid Receptor with Bound Progesterone

X-ray diffraction
2.2Å resolution
PDB entry 2aa5 coloured by chain, front view.
PDB entry 2aa5 coloured by chain, side view.
PDB entry 2aa5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Mineralocorticoid receptor
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Multimeric state: monomeric
Accessible surface area: 12497.4 Å2
Buried surface area: 706.46 Å2
Dissociation area: 353.23 Å2
Dissociation energy (ΔGdiss): -7.69 kcal/mol
Dissociation entropy (TΔSdiss): 4.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140040
Assembly 2
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Assembly Name: Mineralocorticoid receptor
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Multimeric state: monomeric
Accessible surface area: 12324.12 Å2
Buried surface area: 713.57 Å2
Dissociation area: 356.78 Å2
Dissociation energy (ΔGdiss): -7.7 kcal/mol
Dissociation entropy (TΔSdiss): 4.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140040

Macromolecules

Mineralocorticoid receptor
Chains: A, B
Length: 275 amino acids
Theoretical weight: 31.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08235 (Residues: 712-984; Coverage: 28%)
Gene names: MCR, MLR, NR3C2
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Mineralocorticoid receptor in PDB entry 2aa5, assembly 1, front view.
Mineralocorticoid receptor in PDB entry 2aa5, assembly 1, side view.
Mineralocorticoid receptor in PDB entry 2aa5, assembly 1, top view.
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