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Crystal Structures of the Wild-type, Mutant-P1A and Inactivated Malonate Semialdehyde Decarboxylase: A Structural Basis for the Decarboxylase and Hydratase Activities

X-ray diffraction
1.65Å resolution
PDB entry 2aal coloured by chain, front view.
PDB entry 2aal coloured by chain, side view.
PDB entry 2aal coloured by chain, top view.
Source organism: Pseudomonas pavonaceae
Assembly composition:
homo trimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Malonate semialdehyde decarboxylase
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Multimeric state: homo trimer
Accessible surface area: 14232.02 Å2
Buried surface area: 8874.96 Å2
Dissociation area: 4,061.1 Å2
Dissociation energy (ΔGdiss): 43.14 kcal/mol
Dissociation entropy (TΔSdiss): 24.74 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-190201
Assembly 2
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Assembly Name: Malonate semialdehyde decarboxylase
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Multimeric state: homo trimer
Accessible surface area: 14047.21 Å2
Buried surface area: 8922.86 Å2
Dissociation area: 4,086.8 Å2
Dissociation energy (ΔGdiss): 45.87 kcal/mol
Dissociation entropy (TΔSdiss): 24.73 kcal/mol
Symmetry number: 3
PDBe Complex ID: PDB-CPX-190201

Macromolecules

Malonate semialdehyde decarboxylase
Chains: A, B, C, D, E, F
Length: 130 amino acids
Theoretical weight: 14.18 KDa
Source organism: Pseudomonas pavonaceae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9EV83 (Residues: 2-130; Coverage: 99%)
Gene name: msaD
Pfam: Tautomerase enzyme
InterPro:
CATH: Macrophage Migration Inhibitory Factor
SCOP: MSAD-like
Malonate semialdehyde decarboxylase in PDB entry 2aal, assembly 1, front view.
Malonate semialdehyde decarboxylase in PDB entry 2aal, assembly 1, side view.
Malonate semialdehyde decarboxylase in PDB entry 2aal, assembly 1, top view.
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