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Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67.

Byeon IJ, Li H, Song H, Gronenborn AM, Tsai MD
Nat Struct Mol Biol 12 987-93 (2005)
Cited: 51 times
EuropePMC logo PMID: 16244663

Abstract

The forkhead-associated (FHA) domain of human Ki67 interacts with the human nucleolar protein hNIFK, recognizing a 44-residue fragment, hNIFK226-269, phosphorylated at Thr234. Here we show that high-affinity binding requires sequential phosphorylation by two kinases, CDK1 and GSK3, yielding pThr238, pThr234 and pSer230. We have determined the solution structure of Ki67FHA in complex with the triply phosphorylated peptide hNIFK226-269(3P), revealing not only local recognition of pThr234 but also the extension of the beta-sheet of the FHA domain by the addition of a beta-strand of hNIFK. The structure of an FHA domain in complex with a biologically relevant binding partner provides insights into ligand specificity and potentially links the cancer marker protein Ki67 to a signaling pathway associated with cell fate specification.

Reviews - 2aff mentioned but not cited (1)

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Articles - 2aff mentioned but not cited (11)

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Reviews citing this publication (7)

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Related citations provided by authors (1)

  1. Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions.. Li H, Byeon I-JL, Ju Y, Tsai M-D J. Mol. Biol. 335 371-381 (2004)

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