Structure analysis

orally active thrombin inhibitors in complex with thrombin and an exosite decapeptide

X-ray diffraction
2.46Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 12698.79 Å2
Buried surface area: 5147.89 Å2
Dissociation area: 2,049.49 Å2
Dissociation energy (ΔGdiss): 7.96 kcal/mol
Dissociation entropy (TΔSdiss): 18.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-133113

Macromolecules

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Chain: L
Length: 34 amino acids
Theoretical weight: 3.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 330-363; Coverage: 6%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:

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