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Crystal structure of the human inducible form 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

X-ray diffraction
2.1Å resolution
PDB entry 2axn coloured by chain, front view.
PDB entry 2axn coloured by chain, side view.
PDB entry 2axn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
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Multimeric state: monomeric
Accessible surface area: 22796.16 Å2
Buried surface area: 2046.03 Å2
Dissociation area: 344.37 Å2
Dissociation energy (ΔGdiss): 3.44 kcal/mol
Dissociation entropy (TΔSdiss): 3.95 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172609

Macromolecules

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
Chain: A
Length: 520 amino acids
Theoretical weight: 59.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16875 (Residues: 1-520; Coverage: 100%)
Gene name: PFKFB3
Pfam:
InterPro:
CATH:
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 in PDB entry 2axn, assembly 1, front view.
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 in PDB entry 2axn, assembly 1, side view.
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 in PDB entry 2axn, assembly 1, top view.
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