EC 1.3.5.1: Succinate dehydrogenase (quinone)
Reaction catalysed:
Succinate + a quinone = fumarate + a quinol
Systematic name:
Succinate:quinone oxidoreductase
Alternative Name(s):
- Complex II
- SDH
- Succinate dehydrogenase (ubiquinone)
- Succinate dehydrogenase complex
- Succinate:ubiquinone oxidoreductase
- Succinic dehydrogenase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR034804
Domain description:
Fumarate reductase/succinate dehydrogenase, transmembrane subunit
Occurring in:
Occurring in:
IPR027477
Domain description:
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily
Occurring in:
Occurring in:
IPR000701
Domain description:
Succinate dehydrogenase/fumarate reductase type B, transmembrane subunit
Occurring in:
Occurring in:
IPR004489
Domain description:
Succinate dehydrogenase/fumarate reductase iron-sulphur protein
Occurring in:
Occurring in:
IPR015939
Domain description:
Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal
Occurring in:
Occurring in:
IPR037099
Domain description:
Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily
Occurring in:
Occurring in:
IPR003952
Domain description:
Fumarate reductase/succinate dehydrogenase, FAD-binding site
Occurring in:
Occurring in:
IPR014006
Domain description:
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
Occurring in:
Occurring in:
Structure domains
CATH domains
1.10.1060.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2
Homology:
Alpha-helical ferredoxin
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of CATH domain <span class='highlight'>1.10.1060.10 (Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2)</span> in <span class='highlight'>Fumarate reductase iron-sulfur subunit</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 1.10.1060.10 (Fumarate Reductase Iron-sulfur Protein; Chain B, domain 2) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_2_B_CATH_1.10.1060.10_image-200x200.png)
3.50.50.60
Class:
Alpha Beta
Architecture:
3-Layer(bba) Sandwich
Topology:
FAD/NAD(P)-binding domain
Homology:
FAD/NAD(P)-binding domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of CATH domain <span class='highlight'>3.50.50.60 (FAD/NAD(P)-binding domain)</span> in <span class='highlight'>Fumarate reductase flavoprotein subunit</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_1_A_CATH_3.50.50.60_image-200x200.png)
1.20.1300.10
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
3 helical TM bundles of succinate and fumarate reductases
Homology:
Fumarate reductase/succinate dehydrogenase, transmembrane subunit
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of CATH domain <span class='highlight'>1.20.1300.10 (3 helical TM bundles of succinate and fumarate reductases)</span> in <span class='highlight'>Fumarate reductase cytochrome b subunit</span>. Showing 1 copy in chain <span class='highlight'>C</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 1.20.1300.10 (3 helical TM bundles of succinate and fumarate reductases) in Fumarate reductase cytochrome b subunit. Showing 1 copy in chain C.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_3_C_CATH_1.20.1300.10_image-200x200.png)
3.10.20.30
Class:
Alpha Beta
Architecture:
Roll
Topology:
Ubiquitin-like (UB roll)
Homology:
Ubiquitin-like (UB roll)
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of CATH domain <span class='highlight'>3.10.20.30 (Ubiquitin-like (UB roll))</span> in <span class='highlight'>Fumarate reductase iron-sulfur subunit</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 3.10.20.30 (Ubiquitin-like (UB roll)) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_2_B_CATH_3.10.20.30_image-200x200.png)
3.10.20.820
Class:
Alpha Beta
Architecture:
Roll
Topology:
Ubiquitin-like (UB roll)
Homology:
Ubiquitin-like (UB roll)
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of CATH domain <span class='highlight'>3.10.20.820 (Ubiquitin-like (UB roll))</span> in <span class='highlight'>Fumarate reductase flavoprotein subunit</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 3.10.20.820 (Ubiquitin-like (UB roll)) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_1_A_CATH_3.10.20.820_image-200x200.png)
1.20.58.100
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homology:
Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of CATH domain <span class='highlight'>1.20.58.100 (Methane Monooxygenase Hydroxylase; Chain G, domain 1)</span> in <span class='highlight'>Fumarate reductase flavoprotein subunit</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of CATH domain 1.20.58.100 (Methane Monooxygenase Hydroxylase; Chain G, domain 1) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_1_A_CATH_1.20.58.100_image-200x200.png)
SCOP annotations
51934
Class:
Alpha and beta proteins (a/b)
Fold:
FAD/NAD(P)-binding domain
Superfamily:
FAD/NAD(P)-binding domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of SCOP domain <span class='highlight'>51934 (Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain)</span> in <span class='highlight'>Fumarate reductase flavoprotein subunit</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 51934 (Succinate dehydrogenase/fumarate reductase flavoprotein N-terminal domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_1_A_SCOP_51934_image-200x200.png)
56910
Class:
Membrane and cell surface proteins and peptides
Fold:
Heme-binding four-helical bundle
Superfamily:
Fumarate reductase respiratory complex transmembrane subunits
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of SCOP domain <span class='highlight'>56910 (Fumarate reductase respiratory complex cytochrome b subunit, FrdC)</span> in <span class='highlight'>Fumarate reductase cytochrome b subunit</span>. Showing 1 copy in chain <span class='highlight'>C</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 56910 (Fumarate reductase respiratory complex cytochrome b subunit, FrdC) in Fumarate reductase cytochrome b subunit. Showing 1 copy in chain C.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_3_C_SCOP_56910_image-200x200.png)
46549
Class:
All alpha proteins
Fold:
Globin-like
Superfamily:
alpha-helical ferredoxin
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of SCOP domain <span class='highlight'>46549 (Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain)</span> in <span class='highlight'>Fumarate reductase iron-sulfur subunit</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 46549 (Fumarate reductase/Succinate dehydogenase iron-sulfur protein, C-terminal domain) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_2_B_SCOP_46549_image-200x200.png)
54312
Class:
Alpha and beta proteins (a+b)
Fold:
beta-Grasp (ubiquitin-like)
Superfamily:
2Fe-2S ferredoxin-like
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of SCOP domain <span class='highlight'>54312 (2Fe-2S ferredoxin domains from multidomain proteins)</span> in <span class='highlight'>Fumarate reductase iron-sulfur subunit</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 54312 (2Fe-2S ferredoxin domains from multidomain proteins) in Fumarate reductase iron-sulfur subunit. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_2_B_SCOP_54312_image-200x200.png)
46978
Class:
All alpha proteins
Fold:
Spectrin repeat-like
Superfamily:
Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of SCOP domain <span class='highlight'>46978 (Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain)</span> in <span class='highlight'>Fumarate reductase flavoprotein subunit</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 46978 (Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_1_A_SCOP_46978_image-200x200.png)
56426
Class:
Alpha and beta proteins (a+b)
Fold:
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Superfamily:
Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>2bs3</span> contains 2 copies of SCOP domain <span class='highlight'>56426 (Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain)</span> in <span class='highlight'>Fumarate reductase flavoprotein subunit</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 2bs3 contains 2 copies of SCOP domain 56426 (Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain) in Fumarate reductase flavoprotein subunit. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/2bs3_1_A_SCOP_56426_image-200x200.png)