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Structure of protein Ta0514, putative lipoate protein ligase from T. acidophilum with bound lipoic acid

X-ray diffraction
1.89Å resolution
PDB entry 2c8m coloured by chain, front view.
PDB entry 2c8m coloured by chain, side view.
PDB entry 2c8m coloured by chain, top view.
Source organism: Thermoplasma acidophilum DSM 1728
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Lipoate-protein ligase A subunit 1
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Multimeric state: monomeric
Accessible surface area: 10932.09 Å2
Buried surface area: 527.85 Å2
Dissociation area: 263.92 Å2
Dissociation energy (ΔGdiss): -5.36 kcal/mol
Dissociation entropy (TΔSdiss): 3.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190879
Assembly 2
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Assembly Name: Lipoate-protein ligase A subunit 1
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Multimeric state: monomeric
Accessible surface area: 11143.05 Å2
Buried surface area: 527.19 Å2
Dissociation area: 263.6 Å2
Dissociation energy (ΔGdiss): -5.83 kcal/mol
Dissociation entropy (TΔSdiss): 3.13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190879
Assembly 3
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Assembly Name: Lipoate-protein ligase A subunit 1
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Multimeric state: monomeric
Accessible surface area: 10810.21 Å2
Buried surface area: 524.91 Å2
Dissociation area: 262.45 Å2
Dissociation energy (ΔGdiss): -5.94 kcal/mol
Dissociation entropy (TΔSdiss): 3.13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190879
Assembly 4
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Assembly Name: Lipoate-protein ligase A subunit 1
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Multimeric state: monomeric
Accessible surface area: 10444.16 Å2
Buried surface area: 519.31 Å2
Dissociation area: 259.65 Å2
Dissociation energy (ΔGdiss): -5.18 kcal/mol
Dissociation entropy (TΔSdiss): 3.11 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-190879

Macromolecules

Lipoate-protein ligase A subunit 1
Chains: A, B, C, D
Length: 262 amino acids
Theoretical weight: 29.92 KDa
Source organism: Thermoplasma acidophilum DSM 1728
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HKT1 (Residues: 1-262; Coverage: 100%)
Gene names: Ta0514, lplA
Pfam: Lipoyl protein ligase A/B catalytic domain
InterPro:
CATH: Bira Bifunctional Protein; Domain 2
SCOP: LplA-like
Lipoate-protein ligase A subunit 1 in PDB entry 2c8m, assembly 1, front view.
Lipoate-protein ligase A subunit 1 in PDB entry 2c8m, assembly 1, side view.
Lipoate-protein ligase A subunit 1 in PDB entry 2c8m, assembly 1, top view.
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